Prion protein is a key determinant of alcohol sensitivity through the modulation of N-methyl-D-aspartate receptor (NMDAR) activity.
The prion protein (PrP) is WHEY FAC absolutely required for the development of prion diseases; nevertheless, its physiological functions in the central nervous system remain elusive.Using a combination of behavioral, electrophysiological and biochemical approaches in transgenic mouse models, we provide strong evidence for a crucial role of PrP in a